A new antimesenteric functional end-to-end handsewn anastomosis: surgical prevention of anastomotic recurrence in Crohn's disease. Kono T, Ashida T, Ebisawa Y, Chisato N, Okamoto K, Katsuno H, et al. Thus, clinicians should consider the applicability of Kono-S anastomosis in respective institutions. Evidence from this meta-analysis favors the Kono-S anastomosis for CD patients, especially for ileocolic anastomosis. Complications were rare, with a 3% incidence of ileus (CI: 0.01–0.05), a 4% incidence of small bowel obstruction (CI: 0.01–0.10), a 1% incidence of an anastomotic leak incidence (CI: 0.00–0.03), and a 10% incidence of postoperative infection (CI: 0.03–0.20). Endoscopic recurrence after sensitivity analysis was 5% (CI: 0.00–0.15). Surgical recurrence was pooled at an average of 0% (CI: 0.00–0.01) and a reduced mean Rutgeerts score of 1.375 (CI: 0.727–2.023) after Kono-S anastomosis. We identified 676 patients who underwent surgery with a Kono-S anastomosis. Comparative data were analyzed using the Mantel–Haenszel model for dichotomous outcomes and the mean difference for continuous outcomes. Binominal data were analyzed after Freeman–Tukey double-arcsine transformation. We conducted this study to analyze the effectiveness of the Kono-S anastomosis, by searching Medline, Embase, CNKI, and google scholar. Since then, prevailing evidence of the favorable results of the Kono-S anastomosis has been published from around the world. Interleukin-6 meta-analysis obstructive sleep apnea syndrome pediatric and adult individuals plasma serum.Ĭopyright © 2020 Imani, Sadeghi, Khazaie, Emami, Sadeghi Bahmani and Brand.The Kono-S anastomosis was introduced in 2011 as an alternative anastomosis in Crohn’s disease (CD) surgery.
In summary, the meta-analysis and meta-regression confirmed that, compared to healthy controls, individuals with OSAS (children and adults) had higher serum/plasma IL-6 levels. Egger's test revealed a publication bias across the studies for serum and plasma IL-6 levels ( P = 0.00044 and P = 0.01445, respectively). Results of the meta-regression showed that greater age was associated with higher serum IL-6 levels. The pooled analysis of serum and plasma IL-6 levels in children with OSAS compared with controls revealed that only the MD of plasma IL-6 levels was significant (MD = 0.84 pg/ml, P = 0.004). For adults, 37 studies reported significantly higher serum IL-6 levels and 20 reported significantly higher plasma IL-6 levels for those with OSAS than for healthy controls. Sixty-three studies (57 with adults six with children) were included in the present meta-analysis. The results of funnel plots and meta-regression were analyzed by the CMA 2.0 software.
Revman 5 meta regression software#
RevMan 5.3 software was used to calculate the crude mean difference (MD) and 95% confidence interval (CI). Four databases, PubMed/Medline, Scopus, Cochrane Library, and Web of Science, were comprehensively searched to retrieve articles published up to December, 2019, with no further restrictions. The present meta-analysis and meta-regression aimed at comparing plasma and serum levels of IL-6 between individuals (children and adults) with OSAS and healthy controls. Interleukin-6 (IL-6) is one of the most significant inflammatory markers and an excellent proxy for the inflammatory/immune system. Obstructive sleep apnea syndrome (OSAS) is considered a low-grade chronic inflammatory disease.
8 Division of Sport Science and Psychosocial Health, Department of Sport, Exercise and Health, University of Basel, Basel, Switzerland.7 Departments of Physical Therapy, University of Alabama at Birmingham, Birmingham, AL, United States.6 Substance Abuse Prevention Research Center, Kermanshah University of Medical Sciences, Kermanshah, Iran.5 Center for Affective, Stress and Sleep Disorders, Psychiatric Clinics, University of Basel, Basel, Switzerland.4 Students Research Committee, Kermanshah University of Medical Sciences, Kermanshah, Iran.3 Sleep Disorders Research Center, Kermanshah University of Medical Sciences, Kermanshah, Iran.2 Medical Biology Research Center, Kermanshah University of Medical Sciences, Kermanshah, Iran.1 Department of Orthodontics, Kermanshah University of Medical Sciences, Kermanshah, Iran.